김규봉 사진

김규봉 | 약학대학 약학과 (약학관)

  • 직급:
    교수

교수소개

안녕하세요. 독성학연구실 책임자 김규봉입니다. 독성학은 인체의 질병을 유발하는 모든 인자의 기전을 연구하여 인간의 질병을 예방하고 치료하는 것을 연구하는 학문 분야입니다. 따라서, 보다 향상된 삶을 지향하는 것을 목적으로 합니다.

독성학연구실에서는 인체에 질병을 유발하는 물질들에 대하여 주로 연구합니다. 인체에 질병을 유발하는 물질은 우리 주변에 매우 많습니다. 우리가 매일 흡입하는 공기를 예로 들자면, 오존, 일산화탄소, 이산화황, 특히 담배연기 등이 유해하다고 할 수 있습니다. 매일 먹는 식품에는 중금속, 농약 등 미량이지만 유해한 물질들입니다. 이러한 유해 물질이 유해한 작용 즉, 독성작용을 나타내기 위해선 양이 매우 중요합니다. 독성학연구실에서는 독성물질의 인체 노출 양에 대한 연구(독성동태학)를 하며, 이 연구를 통하여 유해물질의 위해성평가(Risk Assessment)를 하고있습니다.

또한, 표적장기 연구로는 간장과 신장 독성을 평가하기 위한 새로운 방법으로 '독성대사체학(Toxicometabolomics)'을 수행하고 있습니다. 독성대사체학은 새로운 연구분야로 독성물질에 반응하는 생체의 대사체를 분석 연구합니다.

학력

  • [1993] 학사 성균관대학교(자연과학캠퍼스) / 약학과
  • [1995] 석사 성균관대학교(자연과학캠퍼스) / 약학과 / 생명약학
  • [2007] 박사 The University of Georgia / 약학과 / 독성학

주요연구분야

Drug(phytochemical)-interaction
Metabolomics
PBPK modeling
Risk assessment
Target organ toxicity

컨설팅 가능 분야

유해물질의 위해성평가
신약개발 및 의약품허가시 필요한 독성자료 작성
의약품 개발
독성대사체학연구

연구업적

  • 연구보고서[20131231] 2013 화장품원료 안전성평가연구사업결과보고서
  • 연구보고서[20131130] 아크릴아마이드의 저용량 노출평가 연구
  • 연구보고서[20131130] 화장품성분중 배합한도 성분의 리스크프로파일링연구(II)-자외선차단성분 및 살균보존성분
  • 연구보고서[20130516] 홍삼과 고혈압치료제, 암로디핀의 약물상호작용 연구
  • 연구보고서[20121207] 약물수송체에의한약물상호작용평가연구
  • 연구보고서[20121130] 자외선차단성분의리스크프로파일링연구
  • 연구보고서[20121130] PBPK 모델을 이용한 아크릴아마이드의 노출 평가 및 위해도 평가 연구
  • 일반논문[20231201] Prediction of skin sensitization using machine learning
  • 일반논문[20230401] Analytical method development and dermal absorption of 2-amino-5-nitrophenol (2A5NP), a hair dye ingredient under oxidative condition
  • 일반논문[20230331] Development of an LC–MS/MS Assay and Toxicokinetic Characterization of Hexamethylenetetramine in Rats
  • 일반논문[20230101] Negligible Toxicokinetic Differences of Glyphosate by Different Vehicles in Rats
  • 일반논문[20221201] Urinary Metabolomics in Young Soccer Players after Winter Training Season
  • 일반논문[20221101] Current trends in read-across applications for chemical risk assessments and chemical registrations in the Republic of Korea
  • 일반논문[20221101] Toxicokinetics, Percutaneous Absorption and Tissue Distribution of Benzophenone‐3, an UV Filtering Agent, in Rats
  • 일반논문[20220901] Analytical Method Development and Dermal Absorption of Pyrogallol, a Hair Dye Ingredient
  • 일반논문[20220701] Prenatal developmental toxicity study of 2,4-dichlorobenzyl alcohol in rats
  • 일반논문[20220603] A Metabolomics Approach to Sulforaphane Efficacy in Secondhand Smoking-Induced Pulmonary Damage in Mice
  • 일반논문[20220601] Pharmacokinetics and the Dermal Absorption of Bromochlorophene, a Cosmetic Preservative Ingredient, in Rats
  • 일반논문[20220301] Microfluidic system with light intensity filters facilitating the application of photodynamic therapy for high-throughput drug screening
  • 일반논문[20220101] Metabolomics profiling of valproic acid-induced symptoms resembling autism spectrum disorders using 1H NMR spectral analysis in rat model
  • 일반논문[20220101] Using intracellular metabolic profiling to identify novel biomarkers of cisplatin-induced acute kidney injury in NRK-52E cells
  • 일반논문[20211201] Effects of tobacco compound 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on the expression of epigenetically regulated genes in lung carcinogenesis
  • 일반논문[20211101] Topical application of celastrol alleviates atopic dermatitis symptoms mediated through the regulation of thymic stromal lymphopoietin and group 2 innate lymphoid cells
  • 일반논문[20211001] Analytical method development and percutaneous absorption of propylidene phthalide, a cosmetic ingredient
  • 일반논문[20211001] Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence
  • 일반논문[20210901] Validation of Quantitative Structure-Activity Relationship (QSAR) and Quantitative Structure-Property Relationship (QSPR) approaches as alternatives to skin sensitization risk assessment
  • 일반논문[20210601] Thirteen-week subcutaneous repeated dose toxicity study of butylparaben and its toxicokinetics in rats
  • 일반논문[20210501] Current opinion on risk assessment of cosmetics
  • 일반논문[20210430] Effect of Application Amounts on In Vitro Dermal Absorption Test Using Caffeine and Testosterone
  • 일반논문[20210401] Metabolomics approach to biomarkers of dry eye disease using H-1-NMR in rats
  • 일반논문[20201001] Para-phenylenediamine, an oxidative hair dye ingredient, increases thymic stromal lymphopoietin and proinflammatory cytokines causing acute dermatitis
  • 일반논문[20200801] Risk assessment of unintentional phthalates contaminants in cosmetics
  • 일반논문[20200601] Effects of anti-wrinkle and skin-whitening fermented black ginseng on human subjects and underlying mechanism of action
  • 일반논문[20200301] Integration of transcriptomics, proteomics and metabolomics identifies biomarkers for pulmonary injury by polyhexamethylene guanidine phosphate (PHMG-p), a humidifier disinfectant, in rats
  • 일반논문[20200201] Novel functions for 2-phenylbenzimidazole-5-sulphonic acid: Inhibition of ovarian cancer cell responses and tumour angiogenesis
  • 일반논문[20190724] Metabolomics approach to serum biomarker for laxative effects of red Liriope platyphylla in loperamide-induced constipation of SD rats
  • 일반논문[20190701] Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats
  • 일반논문[20190601] Risk assessment of volatile organic compounds (VOCs) detected in sanitary pads
  • 일반논문[20190601] The Relationship between Epidemiologic Factors and Usage Pattern of Hair Care Products in Korea
  • 일반논문[20190501] Possible Effects of Radiofrequency Electromagnetic Field Exposure on Central Nerve System
  • 일반논문[20190501] Quantitative structure–activity and quantitative structure–property relationship approaches as alternative skin sensitization risk assessment methods
  • 일반논문[20190415] Risk assessment of triclosan, a cosmetic preservative
  • 일반논문[20190415] Risk assessment of ethylhexyl dimethyl PABA in cosmetics
  • 일반논문[20190415] Risk assessment of drometrizole, a cosmetic ingredient used as an ultraviolet light absorber
  • 일반논문[20190415] Effect of combined exposure to EDTA and zinc pyrithione on pyrithione absorption in rats
  • 일반논문[20190415] Risk assessment of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) used as a preservative in cosmetics
  • 일반논문[20190401] Percutaneous permeability of 1-phenoxy-2-propanol, a preservative in cosmetics
  • 일반논문[20190301] Alternative skin sensitization prediction and risk assessment using proinflammatory biomarkers, interleukin-1 beta (IL-1β) and inducible nitric oxide synthase (iNOS)
  • 일반논문[20190102] 1H NMR toxicometabolomics following cisplatin-induced nephrotoxicity in male rats
  • 일반논문[20190101] Perspectives on trace chemical safety and chemophobia: risk communication and risk management
  • 일반논문[20181115] Analytical method development of methylisothiazolinone, a preservative, in rat plasma using LC-MS/MS
  • 일반논문[20181004] Efficient Transdermal Delivery of DNA Nanostructures Alleviates Atopic Dermatitis Symptoms in NC/Nga Mice
  • 일반논문[20181001] Reversed-Phase High-Performance Liquid Chromatographic Method for the Determination of Permaton Red (D&C Red No. 36) in Cosmetics
  • 일반논문[20180901] Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice
  • 일반논문[20180701] IL-1 and IL-1 as alternative biomarkers for risk assessment and the prediction of skin sensitization potency
  • 일반논문[20180701] Metabolic profiling of eccentric exercise-induced muscle damage in human urine
  • 일반논문[20180501] Socioeconomic factors influencing cosmetic usage patterns
  • 일반논문[20180401] Risk assessment of N-nitrosodiethylamine (NDEA) and N-nitrosodiethanolamine (NDELA) in cosmetics
  • 일반논문[20180401] Non-cancer, cancer, and dermal sensitization risk assessment of heavy metals in cosmetics
  • 일반논문[20180301] Potentiation of skin TSLP production by a cosmetic colorant leads to aggravation of dermatitis symptoms
  • 일반논문[20171101] Analysis of metabolomic patterns in thoroughbreds before and after exercise
  • 일반논문[20170801] Assessment of exposure for baby cosmetic care products in a Korean population
  • 일반논문[20170501] Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens
  • 일반논문[20170301] Integration of Traditional and Metabolomics Biomarkers Identifies Prognostic Metabolites for Predicting Responsiveness to Nutritional Intervention against Oxidative Stress and Inflammation
  • 일반논문[20170301] Anti‑wrinkle effect of fermented black ginseng on human fibroblasts
  • 일반논문[20160601] Metabolic profiling of antioxidant supplement with phytochemicals using plasma 1H NMR-based metabolomics in humans
  • 일반논문[20160101] Discovery of urinary metabolomic biomarkers for early detection of acute kidney injury
  • 일반논문[20151101] Negligible Pharmacokinetic Interaction of Red Ginseng and Losartan, an Antihypertensive Agent, in Sprague-Dawley Rats
  • 일반논문[20151101] Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC-MS/MS with polarity switching: Application to ADME studies
  • 일반논문[20151001] A sensitive LC-ESI-MS/MS method for the quantification of avobenzone in rat plasam and skin layers: Application to a topical administration study
  • 일반논문[20150801] High-Throughput Cytotoxicity Testing System of Acetaminophen Using a Microfluidic Device (MFD) in HepG2 Cells
  • 일반논문[20150601] Safety Evaluation of Polyethylene Glycol (PEG) Compounds for Cosmetic Use
  • 일반논문[20150101] Determination of acrylamide and glycidamide in various biological matrices by liquid chromatogrphy-tandom mass spectrometry and its application to a pharmacokinetic study
  • 일반논문[20141201] Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells
  • 일반논문[20141001] Negligible pharmacokinetic interaction of red ginseng and antihypertensive agent amlodipine in Sprague-Dawley rats
  • 일반논문[20141001] Evaluation of cadmium-induced nephrotoxicity using urinary metabolomics profiles in Sprague-Dawley male rats
  • 일반논문[20140801] a-linolenic acid: nutritional, pharmacological and toxicological evaluation
  • 일반논문[20140520] HPLC-MS/MS method for the pharmacokinetics of homosalate after topical administration in rats
  • 일반논문[20140330] Metabolomics approach to serum biomarker for loperamide-induced constipation in SD rats
  • 일반논문[20140220] Percutaneous Absorption, Disposition, and Exposure Assessment of Homosalate, a UV Filtering Agent, in Rats
  • 일반논문[20140120] Safety of red ginseng oil for single oral administration in Sprague-Dawley rats
  • 일반논문[20131203] Pattern recognition analysis for hepatotoxicity induced by acetaminophen using plasma and urinary 1H NMR-based metabolomics in humans
  • 일반논문[20131101] Potential metabolomic biomarkers for evaluation of adriamycin efficacy using a urinary 1H-NMR spectroscopy
  • 일반논문[20130929] Mutagenic Assessment of Olmesartan Cilexetil by Bacterial Mutation Assay
  • 일반논문[20130401] Safety evaluation and risk assessment of d-limonene
  • 일반논문[20120413] Nuclear magnetic resonance-based metabolomics for prediction of gastric damage induced by indomethacin in rats
  • 저서/역서[20130315] 질환별로 본 건강기능식품학(3판)
  • 저서/역서[20120305] 제약공학개론(개정판)
  • 학술발표[20140403] Toxicometabolomics approach for hepatotoxicity assessment in drug development
  • 학술발표[20140324] Toxicometabolomics approach to prediction of hepatotoxicity by troglitarzone/LPS in rats
  • 학술발표[20131030] Toxicometabolomics of hepatic alteration by acetaminophen in humans and rats
  • 학술발표[20130903] Pharmacokinetics and tissue distribution of acrylamide and its active metabolite, glycidamide in rats
  • 학술발표[20130903] Pharmacokinetics and percutaneous absorption of benzophenone-3 from sunscreen formulations in rats
  • 학술발표[20130903] Pharmacokinetics and tissue distribution of benzophenone-3, a UV filtering agent in rats
  • 학술발표[20130702] Risk assessment of cadmium using physiologically-based pharmacokinetic (PBPK) modeling for Korean population
  • 학술발표[20130419] Metabolomics Approach to Determination of hepatic Alteration by Acetaminophen using Plasma and Urinary 1H NMR Spectral Data in Humans and Rats
  • 학술발표[20120720] Toxicometabolomics approach to investigation of black ginseng on prevention of acute hepatitis in Sprague-Dawley rats
  • 학술발표[20120718] Toxicometabolomics and urinary biomarkers for nephrotoxicity
  • 학술발표[20120619] Clinical Metabolomics using 1H NMR Spectral Data in Acute Drug-induced Liver Injury
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