After gradautation of Seoul National University Medical School (M.D. degree) in 1991, Dr. Seong entered Ph.D. course of Seoul National University Medical School. He got Ph.D. with a Thesis of "Molecular Cloning and Sequeocing of Rat Guanine Aminoydrolase cDNA" in 1997. He started tenure tract in Department of Biochemistry, College of Medicine, Dankook University in 1995. Before 2000, He worked in the field purine nucleotide metabolism and cloning of genes in relevant field. At the end of 1990s he worked with cloning and characterization of novel cytoskeleton related protein named CKAP2 (cytoskeleton associated protein 2) which was obtained from stomach cancer sample by Diferential Display PCR. During the characterization of CKAP2 he moved his research to cell cycle regulation. From 2000 to 2003 he visited National Cancer Center as visiting fellow and carried out research in field of cell cycle, mitosis, cell cycle check point regulation with polo-like kinase and cdc2. After return to Dankook University he worked with cellular senenscence related with cdk1 inhibition and contromal signaling network. After participation of World ClassUniversity Project (from 2009-2013) he returned to medical school of Dankook Uiversity and carries out research on the effects of kinase signaling relevant to DNA damage Growth factor receptor inhibition on cell survival and proliferation.
Confession, Faithfulness, Sincerity, Planning, Integration
Characterization of novel cdk inhibotor BMI-1026
Cloning and characterization of CKAP2 protein
Regulation of senescence and Heterochromatin formation by direct inhibition of cdks
Role of polo box and mitosis progression