단국대학교

• 학과소개
• 교수소개
• 교과과정

학력

• [2005] 학사 중앙대학교 / 약학부
• [2007] 석사 중앙대학교 / 약학과 / 약물전달시스템
• [2010] 박사 중앙대학교 / 약학과 약제학 전공 / 약물전달시스템

주요연구분야

나노현탁기술 기반 장기 지속형 주사제형 설계 연구
나노기술 기반 피부 흡수 전달 개선연구
Chemicals 와 peptides 후보 물질에 대한 preformulation 및 formulation 연구

컨설팅 가능 분야

1. 장기 지속형 주사제형 설계 연구
2. 신약 후보물질에 대한 전임상 및 IND 신청용 제형 설계 연구
3. 액상 제형 (주사제, 점안제 등) 설계 연구

연구업적

• 일반논문[20240302] Evaluation of the Ejection Pressure for Tracking Internal Cracks during Compaction in Bilayer Tablet Formulations Using Experimental and Finite Element Methods
• 일반논문[20240129] Tricaprylin-based drug crystalline suspension for intramuscular long-acting delivery of entecavir with alleviated local inflammation
• 일반논문[20240125] Design of High-Payload Ascorbyl Palmitate Nanosuspensions for Enhanced Skin Delivery
• 일반논문[20240108] Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression technique with shortened disintegration time
• 일반논문[20240101] Development of core–shell structured nanoparticle for sequential release of tariquidar and docetaxel to overcome multi drug-resistant cancer
• 일반논문[20231026] The Effect of Compression Pressure on the First Layer Surface Roughness and Delamination of Metformin and Evogliptin Bilayer and Trilayer Tablets
• 일반논문[20230721] Exploration of lipidic prodrug-loaded oil depot system for intramuscular prolonged delivery of entecavir
• 일반논문[20230614] Novel Bioequivalent Tablet of Solifenacin Succinate Prepared Using Direct Compression Technique for Improved Chemical Stability
• 일반논문[20230601] A simple method to determine lycopene in solid supplementary food preparations using saponification and liquid chromatography
• 일반논문[20230301] Neutral Oil-Incorporated Liposomal Nanocarrier for Increased Skin Delivery of Ascorbic Acid
• 일반논문[20230201] Functionalized Lipid Nanocarriers for Simultaneous Delivery of Docetaxel and Tariquidar to Chemoresistant Cancer Cells
• 일반논문[20230101] Design of Novel Tricaprylin-Incorporated Multi-Layered Liposomal System for Skin Delivery of Ascorbic Acid with Improved Chemical Stability
• 일반논문[20230101] Assessment of hydrophobic-ion paired insulin incorporated SMEDDS for the treatment of diabetes mellitus
• 일반논문[20221201] A Sensitive, Efficient, and Cost-Effective Method to Determine Rotigotine in Rat Plasma Using Liquid-Liquid Extraction (LLE) and LC-MRM
• 일반논문[20221101] Effect of Dispersion Medium on Pharmacokinetic Profile of Rotigotine Crystalline Suspension following Subcutaneous Injection
• 일반논문[20220801] Design of Montelukast Nanocrystalline Suspension for Parenteral Prolonged Delivery
• 일반논문[20220701] Local retention efficacy of steroid-loaded PLGA microspheres in epidural injection
• 일반논문[20220603] Synergistic co-administration of docetaxel and curcumin to chemoresistant cancer cells using PEGylated and RIPL peptide-conjugated nanostructured lipid carriers
• 일반논문[20220501] Co-administration of tariquidar using functionalized nanostructured lipid carriers overcomes resistance to docetaxel in multidrug resistant MCF7/ ADR cells
• 일반논문[20220401] Enhanced dissolution and bioavailability of revaprazan using self-nanoemulsifying drug delivery system
• 일반논문[20220101] Effect of particle size on in vivo performances of long-acting injectable drug suspension
• 일반논문[20211101] High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation
• 일반논문[20210701] Montelukast microsuspension with hypromellose for improved stability and oral absorption
• 일반논문[20210301] Effect of Penetration Enhancers on Toenail Delivery of Efinaconazole from Hydroalcoholic Preparations
• 일반논문[20201201] A simple and efficient method to determine montelukast in rat plasma using liquid-liquid extraction and tandem mass spectrometry
• 일반논문[20201101] Current status of the development of intravesical drug delivery systems for the treatment of bladder cancer
• 일반논문[20201001] Nanocomplex System of Bupivacaine with Dextran Sulfate for Parenteral Prolonged Delivery
• 일반논문[20200901] Preparation and in vivo pharmacokinetic evaluation of stable microemulsion system of cholecalciferol
• 일반논문[20200601] Enhanced docetaxel delivery using sterically stabilized RIPL peptideconjugated nanostructured lipid carriers: In vitro and in vivo antitumor efficacy against SKOV3 ovarian cancer cells
• 일반논문[20200201] Effect of Oily Ingredients and Solid Adsorbents on the Chemical Stability of a Solid Dosage Form of Lubiprostone
• 일반논문[20200101] Montelukast Nanocrystals for Transdermal Delivery with Improved Chemical Stability
• 일반논문[20191001] Quantitative assessment of steroid amount in the tissue after epidural steroid injection: a new rabbit model
• 일반논문[20190801] Design and In Vivo Pharmacokinetic Evaluation of Triamcinolone Acetonide Microcrystals-Loaded PLGA Microsphere for Increased Drug Retention in Knees after Intra-Articular Injection
• 일반논문[20190408] Improved Drug Loading and Sustained Release of Entecavir-loaded PLGA Microsphere Prepared by Spray Drying Technique
• 일반논문[20190304] Pharmacokinetics and four-week repeated-dose toxicity of hyaluronic acid and ketorolac combination following intra-articular administration in normal rats
• 일반논문[20190104] Recent advances in intra-articular drug delivery systems to extend drug retention in joint
• 일반논문[20181001] Sterically Stabilized RIPL Peptide-Conjugated Nanostructured Lipid Carriers: Characterization, Cellular Uptake, Cytotoxicity, and Biodistribution
• 일반논문[20181001] Immediate release tablet formulation of varenicline salicylate and comparative pharmacokinetic study in human volunteers
• 일반논문[20180901] Effect of Poly(Lactide-Co-Glycolide) Nanoparticles on Local Retention of Fluorescent Material: An Experimental Study in Mice
• 일반논문[20180901] Design and in vivo evaluation of entecavir-3-palmitate microcrystals for subcutaneous sustained delivery
• 일반논문[20180801] Novel Extended-Release Multiple-Unit System of Imidafenacin Prepared by Fluid-Bed Coating Technique
• 일반논문[20180701] Rapid quantitation of atorvastatin in process pharmaceutical powder sample using Raman spectroscopy and evaluation of parameters related to accuracy of analysis
• 일반논문[20180601] RIPL peptide-conjugated nanostructured lipid carriers for enhanced intracellular drug delivery to hepsin-expressing cancer cells
• 일반논문[20180501] Microsuspension of fatty acid esters of entecavir for parenteral sustained delivery
• 일반논문[20180401] Formulation and in vivo pharmacokinetic evaluation of ethyl cellulose-coated sustained release multiple-unit system of tacrolimus
• 일반논문[20180401] Combined Poly(Lactide-Co-Glycolide) Microspheres Containing Diphtheria Toxoid for a Single-shot Immunization
• 일반논문[20180301] Synthesis and Physicochemical Evaluation of Entecavir-Fatty Acid Conjugates in Reducing Food Effect on Intestinal Absorption
• 일반논문[20170501] Formulation and Analgesic Effect of Sodium Hyaluronate and Magnesium Sulfate Combination in Rats Following Intra-articular Injection
• 일반논문[20170501] Colon-targeted delivery of solubilized bisacodyl by doubly enteric-coated multiple-unit tablet
• 일반논문[20170501] Docetaxel-loaded RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated liposomes: Drug release, cytotoxicity, and antitumor efficacy
• 일반논문[20170501] Surface modification of lipid-based nanocarriers for cancer cell-specific drug targeting
• 일반논문[20170301] A Polyvinylpyrrolidone-Based Supersaturable Self-Emulsifying Drug Delivery System for Enhanced Dissolution of Cyclosporine A
• 일반논문[20170201] Surface-Modification of RIPL Peptide-Conjugated Liposomes to Achieve Steric Stabilization and pH Sensitivity
• 일반논문[20170101] Facilitated saliva secretion and reduced oral inflammation by a novel artificial saliva system in the treatment of salivary hypofunction
• 일반논문[20161201] Determination of piroxicam from rat articular tissue and plasma based on LC–MS/MS
• 일반논문[20161101] Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection
• 일반논문[20160901] A Novel Stable Crystalline Triamcinolone Acetonide-loaded PLGA Microsphere for Prolonged Release After Intra-Articular Injection
• 일반논문[20160601] In vivo gastric residence and gastroprotective effect of floating gastroretentive tablet of DA-9601, an extract of Artemisia asiatica, in beagle dogs
• 일반논문[20160501] Chitosan-Based Film of Tyrothricin for Enhanced Antimicrobial Activity against Common Skin Pathogens Including Staphylococcus aureus
• 일반논문[20160401] Multiple-unit tablet of probiotic bacteria for improved storage stability, acid tolerability, and in vivo intestinal protective effect
• 일반논문[20160301] Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system
• 일반논문[20160201] Improved oral absorption of tacrolimus by a solid dispersion withhypromellose and sodium lauryl sulfate
• 일반논문[20160101] Enteric-coated tablet of risedronate sodium in combination with phytic acid, a natural chelating agent, for improved oral bioavailability
• 일반논문[20160101] Formulation and in vivo evaluation of probiotics-encapsulated pelletswith hydroxypropyl methylcellulose acetate succinate (HPMCAS)
• 일반논문[20160101] A rapid and sensitive method to determine tacrolimus in rat whole blood using liquid-liquid extraction with mild temperature ultrasonication and LC-MS/MS
• 일반논문[20151201] Design of Multifunctional Liposomal Nanocarriers for Folate Receptor-Specific Intracellular Drug Delivery
• 일반논문[20151201] Fujicalin-based solid supersaturable self-emulsifying drug delivery system (S-SEDDS) of tacrolimus for enhanced dissolution rate and oral absorption
• 일반논문[20150901] Enhanced dissolution rate of dronedarone hydrochloride via preparation of solid dispersion using vinylpyrrolidone-vinyl acetate copolymer (Kollidone VA64)
• 일반논문[20150801] Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint
• 일반논문[20150701] Reduced Food-Effect on Intestinal Absorption of Dronedarone by Self-microemulsifying Drug Delivery System (SMEDDS)
• 일반논문[20150401] Preparation of Solid Dispersion of Dronedarone Hydrochloride with Soluplus® by Hot Melt Extrusion Technique for Enhanced Drug Release
• 일반논문[20150115] Improved oral absorption of dutasteride via Soluplus®-based supersaturable self-emulsifying drug delivery system (S-SEDDS)
• 일반논문[20141001] Improved oral absorption and chemical stability of everolimus via preparation of solid dispersion using solvent wetting technique
• 일반논문[20140930] A Method to Monitor Dutasteride in Rat Plasma Using Liquid-Liquid Extraction and Multiple Reaction Monitoring: Comparisons and Validation
• 일반논문[20140901] Design of pH-responsive alginate raft formulation of risedronate for reduced esophageal irritation
• 일반논문[20140901] Four-week toxicity and toxicokinetics of piroxicam and hyaluronic acid combination following intra-articular injection in normal rats
• 일반논문[20140806] RIPL peptide (IPLVVPLRRRRRRRRC)-conjugated liposomes for enhanced intracellular drug delivery to hepsin-expressing cancer cells
• 일반논문[20140801] Improved skin delivery of voriconazole with a nanostructured lipid carrier-based hydrogel formulation
• 일반논문[20140720] Preparation of Solid Dispersion of Everolimus in Gelucire 50/13 using Melt Granulation Technique for Enhanced Drug Release
• 일반논문[20140530] Comparison of Piroxicam Pharmacokinetics and Anti-Inflammatory Effect in Rats after Intra-Articular and Intramuscular Administration
• 일반논문[20130315] Folic acid-tethered Pep-1 peptide-conjugated liposomal nanocarrier for enhanced intracellular drug delivery to cancer cells: conformational characterization and in vitro cellular uptake evaluation
• 일반논문[20120501] In situ intestinal permeability and in vivo absorption characteristics of olmesartan medoxomil in self-microemulsifying drug delivery system
• 일반논문[20111101] Immediate release of ibuprofen from Fujicalin®-based fast-dissolving self-emulsifying tablets
• 일반논문[20111001] Tat peptide-admixed elastic liposomal formulation of hirsutenone for the treatment of atopic dermatitis in NC/Nga mice
• 일반논문[20110801] Design of Pep-1 peptide-modified liposomal nanocarrier system for intracellular drug delivery: conformational and physical characterizations, and cell uptake evaluation
• 일반논문[20110101] Pep-1 Peptide-modified liposomal carriers for intracellular delivery of gold nanoparticles
• 일반논문[20101201] Pep-1 peptide-conjugated elastic liposomal formulation of taxifolin glycoside for the treatment of atopic dermatitis in NC/Nga mice.
• 일반논문[20101001] Pharmacologically active metabolites of currently marketed drugs: potential resources for new drug discovery and development
• 일반논문[20100801] Effect of topical application and intraperitoneal injection of oregonin on atopic dermatitis (AD) in NC/Nga mice
• 일반논문[20100701] Influence of liposome type and skin model upon skin permeation and accumulation properties of genistein
• 일반논문[20100301] Highly spherical and deformable chitosan microspheres for arterial embolization
• 일반논문[20100201] Identification and assessment of permeability enhancing vehicles for transdermal delivery of glucosamine hydrochloride
• 일반논문[20100101] Facilitated skin permeation of oregonin by elastic liposomal formulations and suppression of atopic dermatitis in NC/Nga mice
• 일반논문[20091201] Bioavailability enhancing activities of natural compounds from medicinal plants
• 일반논문[20091201] Self-microemulsifying formulation-based oral solution of Coenzyme Q10
• 일반논문[20091101] Solubilized formulation of olmesartan medoxomil for enhancing oral bioavailability in rats
• 일반논문[20090901] Enhanced immune response after subcutaneous injection of diphtheria toxoid-loaded bioerodible microspheres
• 지식재산권[20180110] 사이클로스포린을 포함하는 약학 조성물(Pharmaceutical composition comprising cyclosporine)
• 지식재산권[20171019] 엔테카비어 지방산 에스테르 유도체 수성현탁액의 안정화 조성물
• 지식재산권[20171019] 엔테카비어 지방산 에스테르 유도체를 포함하는 주사 투여용 데포 제제
• 지식재산권[20170929] 히알루론산과 마그네슘을 포함하는 골관절염 치료를 위한 안정한 액상 조성물
• 지식재산권[20170726] 골관절염 예방 또는 치료용, 또는 관절 통증 완화용 주사제 조성물(COMPOSITION FOR PREVENTING OR TREATING OSTEOARTHRITIS, OR FOR RELIEVING JOINT PAIN)
• 지식재산권[20161007] 지방산이 결합된 엔테카비어 유도체 화합물 및 이의 약학적 용도
• 지식재산권[20160823] 히알루론산과 마그네슘을 포함하는 골관절염 치료를 위한 조성물
• 지식재산권[20160809] 안정한 결정형 약물을 포함하는 고분자 미립구 및 그 제조방법
• 지식재산권[20151229] 사이클로스포린을 포함하는 약학 조성물
• 지식재산권[20151229] 사이클로스포린을 포함하는 약학 조성물
• 지식재산권[20151130] 타크로리무스를 포함하는 고형 제제
• 지식재산권[20150901] 관절강 투여 약물용 담체
• 지식재산권[20150708] 골관절염 예방 또는 치료용, 또는 관절 통증 완화용 주사제 조성물
• 지식재산권[20150331] 타크로리무스의 경구용 과포화성 마이크로에멀젼 조성물
• 지식재산권[20120524] 올메사르탄메독소밀 함유 자가유화 약물전달시스템 조성물 및 이의 제조방법(Self-Microemulsifying Drug Delivery System Composition Containing Olmesartanmedoxomil and Method for Preparing the Same)
• 지식재산권[20120524] 안정화 및 가용화된 시롤리무스 유도체 조성물의 제조방법(Method of preparing a stabilized and solubilized formulation of sirolimus derivatives)
• 지식재산권[20120315] 탄력성이 있고 구형이며 일정한 크기를 갖는 키토산 마이크로스피어를 제조하는 방법(Manufacturing method for spherical and elastic chitosan microsphere having regular size)
• 지식재산권[20120306] 세포투과성 펩타이드 표면 결합 나노 리포좀 및 이를 포함하는 항-아토피 조성물(Cell Penetrating Peptide Modified Nanoliposome and Anti-Atopic Composition Comprising the Same)
• 지식재산권[20120302] 초상자성 산화철 나노입자를 포함하는 색전제 및 그 제조 방법(Emboli comprising superparamagnetic iron oxide nanoparticles (SPIOs)-embbeded microparticulates and preparation method thereof)
• 지식재산권[20120302] 초상자성 산화철 나노입자 탑재 고분자 미세구의 제조 방법(Preparation method for superparamagnetic iron oxide nanoparticles (SPIOs)-loaded polymeric microspheres)
• 학술발표[20151120] A novel surfactant-incorporated solid dispersion of tacrolimus for rapid and profound drug release
• 학술발표[20151120] Improved oral absorption of dronedarone via preparation of self-microemulsifying drug delivery system (SMEDDS)
• 학술발표[20151120] Enhanced oral absorption of tacrolimus by solidified supersaturable self-emulsifying drug delivery system (S-SEDDS)
• 학술발표[20151119] Prolonged retention of cationic nanoparticles in synovial cavity by electrostatic interaction with hyaluronate after intra-articular injection
• 학술발표[20150424] Preclinical assessment of toxicity and toxicokinetics of piroxicam after intra-articular injection in normal rats
• 학술발표[20150423] Pharmacokinetics and therapeutic efficacy of piroxicam, a long acting non-steroidal anti-inflammatory drug, after intra-articular injection in osteoarthritis-induced rats
• 학술발표[20150423] Increased dissolution rate of dronedarone hydrochloride via preparation of Soluplus-based solid dispersion using hot-melt extrusion technique
• 학술발표[20130426] Design of cell penetrating peptide-modified liposomal nanocarriers for enhanced topical and intracellular drug delivery

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