단국대학교

• 학과소개
• 교수소개
• 교과과정

교수소개

1991년 서울대학교 의과대학을 졸업하고 동 대학원에서 석사(1993) 박사
(1997)학위를 취득 하였다. 대학원과정에서 퓨린염기 이화대사 효소인
guanine deaminase를 정제하고 클로닝하였으며 신경생화학연구로서 세포의
증식과 분열에 중요한 역할을 하는 단백질 인산화 효소인MAPkinase의 신호
전달에 관하여 연구하였다. 1990년대 말부터 세포분열과정 의 세포골격단백질
인 CKAP2에 관하여 연구를 시작하였고 이를 계기로 세포주기와 세포분열연구
를 위하여 미국으로 연구를 나갔고 미국 국립암센타에서 세포분열및 세포분
열 check point 조절에 중요한 역할을 하는 polo kinase와 cdk에 대한 연구를
주로 하였으며 cdk 의 선택적 억제를 통한 암세포치료에 대하여 연구하였다.
2009년부터 2013년까지 세계수준의 연구중심대학 사업 (대학원 나노바이오의과학과)에 참여하였고 현재는 다시 의과대학 의예과에 복귀하였다.
현재는 주로 세포의 성장및 생존의 제어에 관여하는 인산화 신호전달 경로 그리고 이와 관련된 유전체, 단백질체의 변화에 대하여 연구하고 있다.

학력

• [1991] 학사 서울대학교 / 의학
• [1993] 석사 서울대학교 / 의학 / 생화학
• [1997] 박사 서울대학교 / 의학 / 생화학

주요연구분야

guanine deaminase의 뇌조직에서의 역할
영양학, 아미노산 대사
암발생, 세포사멸, 노화 그리고 세포주기 조절
세포주기 체크포인트
항암제 내성의 단백질 인산화 신호전달 경로
세포사멸 기능억제 암세포에서의 세포사멸에 관련된 신호전달 경로
유전체 발현 분석

컨설팅 가능 분야

의학생화학, 임상영양학, 인체 대사학
암세포생물학, 세포주기 및 세포분열
생체세포 영상기술(confocal microscope, live cell imaging)및 응용
세포주기 분석및 응용
유전물질 전달체로서의 아데노 바이러스, 렌티바이러스
유전체 발현 분석

연구업적

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• 일반논문[20230824] Beta-Transducin Repeats-Containing Proteins as an Anticancer Target
• 일반논문[20221101] Inhibition of I kappa B Kinase Is a Potential Therapeutic Strategy to Circumvent Resistance to Epidermal Growth Factor Receptor Inhibition in Triple-Negative Breast Cancer Cells
• 일반논문[20220101] Ribosomal Protein S6: A Potential Therapeutic Target against Cancer?
• 일반논문[20210701] Doxycycline potentiates the anti-proliferation effects of gemcitabine in pancreatic cancer cells
• 일반논문[20210601] Potentiating Therapeutic Effects of Epidermal Growth Factor Receptor Inhibition in Triple-Negative Breast Cancer
• 일반논문[20210401] Anaplastic lymphoma kinase inhibitor NVP-TAE684 suppresses the proliferation of human pancreatic adenocarcinoma cells
• 일반논문[20210301] Dual Inhibition of AKT and MEK Pathways Potentiates the Anti-Cancer Effect of Gefitinib in Triple-Negative Breast Cancer Cells
• 일반논문[20200701] Ectopic Overexpression of Coiled-Coil Domain Containing 110 Delays G2/M Entry in U2-OS Cells
• 일반논문[20180301] Inhibition of RPTOR overcomes resistance to EGFR inhibition in triple-negative breast cancer cells
• 일반논문[20170901] Silencing of NRF2 reduces the expression of ALDH1A1 and ALDH3A1 and sensitizes to 5-FU in pancreatic cancer cells
• 일반논문[20150701] Co-treatment with BEZ235 Enhances Sensitivity of BRCA1-negative Breast Cancer Cells to Olaparib
• 일반논문[20150701] Dual inhibition of EGFR and MET induces synthetic lethality in triple-negative breast cancer cells through downregulation of ribosomal protein S6
• 일반논문[20150201] β-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
• 일반논문[20141201] HER2 confers drug resistance of human breast cancer cells through activation of NRF2 by direct interaction
• 일반논문[20140601] Combination of dasatinib and gemcitabine reduces the ALDH1A1 expression and the proliferation of gemcitabine-resistant pancreatic cancer MIA PaCa-2 cells
• 일반논문[20140301] Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine
• 일반논문[20131001] Inhibition of checkpoint kinase 2 (CHK2) enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine
• 일반논문[20130501] Inhibition of the PI3K/AKT pathway potentiates cytotoxicity of EGFR kinase inhibitors in triple-negative breast cancer cells.
• 일반논문[20121201] BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells.
• 일반논문[20121201] Genomewide transcription profiles altered by BMI-1026 and Roscovitine and its implication in cellular senescence
• 일반논문[20120901] Aldehyde dehydrogenase 1A1 confers intrinsic and acquired resistance to gemcitabine in human pancreatic adenocarcinoma MIA PaCa-2 cells.
• 일반논문[20120701] Exploring Protein Kinase Inhibitors: Unveiling Gemcitabine Resistance in Pancreatic Cancer
• 일반논문[20120628] BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site.
• 일반논문[20120401] Exploring Protein Kinase Inhibitors Potentiating Gemcitabine Efficacy in Pancreatic Cancer
• 일반논문[20120301] Transforing growth factor beta receptor I inhibitor sensitizes drug-resistant pancreatic cancer cells to Gemcitabine
• 일반논문[20120101] ZSTK474, a PI3K inhibitor, suppresses proliferation and sensitizes human pancreatic adenocarcinoma cells to gemcitabine
• 일반논문[20100813] An Insect Multiligand Recognition Protein Functions as an Opsonin for the Phagocytosis of Microorganisms
• 일반논문[20090601] Depletion of BubR1 promotes premature centrosomal localization of cyclin B-1 and accelerates mitotic entry
• 일반논문[20090601] Cdk1-Cyclin B1-mediated Phosphorylation of Tumor-associated Microtubule-associated Protein/Cytoskeleton-associated Protein 2 in Mitosis
• 일반논문[20081101] Immune evasion of Enterococcus faecalis by an extracellular gelatinase that cleaves C3 and iC3b.
• 일반논문[20080831] Transient phosphorylation of tumor associated microtubule associated protein (TMAP)/cytoskeleton associated protein 2 (CKAP2) at Thr-596 during early phases of mitosis.
• 일반논문[20080801] BMI-1026 treatment can induce SAHF formation by activation of Erk1/2
• 일반논문[20080115] Mechanisms of mammalian polo-like kinase 1 (Plk1) localization: Self- versus non-self-priming
• 일반논문[20071231] The centrosomal localization of KM-HN-1(MGC33607) dependson the leucine zipper motif and the C-terminal coiled-coil domain
• 일반논문[20070301] Functional Importance of the Anaphase-Promoting complex-cdh1 mediated Degradation of TMAP/CKAP2 in Regulation of Spindle Function and Cytokinesis
• 일반논문[20061103] Self-regaulated Plk1 Recruitment to kinatochores by the Plk1-PBIP interaction is critical for proper chromosome segregation
• 일반논문[20061101] Requirement of hCenexin for proter mitotic functions of polo-like kinase 1 at the centrosomes
• 일반논문[20060718] A cytoskelton-associated protein, TMAP/CKAP2 is involved in the proliferation of human foreskin fibroblasts
• 일반논문[20040401] Requirement for Bbp1p in the Proper Mitotic Functions of Cdc5p in S. cerevisiae
• 일반논문[20031115] Up-regulation of cytoskeletal-associated protein 2 in primary human gastric adenocarcinomas
• 일반논문[20031101] Characterization of a novel cyclin-dependent kinase 1 inhibitor, BMI-1026
• 일반논문[20020830] A spindle Checkpoint Attest and a Cytokinesis Failure by the Dominant-negative Polo-Box Domain of Plk1 in U-2 OS Cells
• 일반논문[20000429] 자궁경부암에서 FHIT 유전자의 단백질 발현및 이형성 소실
• 일반논문[19990430] 흰쥐 뇌조직의 발달에 따른 Guanine Deaminase의 발현양상
• 일반논문[19990425] Characterization of the altreration of cell cycle parameters associated with v-src overexpression.
• 일반논문[19981231] 대장균에서 재조합 Rat Guanine deaminase 유전자의 발현,정제 및 분석
• 일반논문[19980425] Molecular Screening and Analysis of Ligand Proteins Associating with Unique-SH3 Domain of c-Yes
• 일반논문[19980325] 부분 요도폐색이 방광의 콜라젠 유형 Ⅰ,Ⅲ,Ⅳ 및 Matrix-Metalloproteinase(MMP)-2 유전자 발현에 미치는
• 일반논문[19970701] 백서 방광 출구 부분 폐색에서 방광의 inducible nitric oxide sysnthase(iNOS)의 발현 변화
• 일반논문[19970601] Electroconvulsive shock increase the phosphorylation of cyclic AMP response element binding protein
• 일반논문[19970410] GDA-11 유전자의 클론화와 핵산 염기 서열 분석
• 일반논문[19970301] Central nervous system involvement in patients with scrub typhus
• 일반논문[19970228] 흰쥐 Guanine aminohydrolase cDNA클로닝 및 염기서열분석
• 일반논문[19961002] 흰쥐 간 quanine aminohydrolase의 펩타이드 서열분석
• 일반논문[19961001] Molecular clonig of putative Yes unique domain binding protein
• 일반논문[19961001] 소 뇌 Guanine aminohydrolase 정제와 특성에 관한 연구
• 일반논문[19960701] 새로 개원한 병원 중환자실에서 발생한 다제 내성 Acinetobacter baumani에 의한 집단 병원감염
• 일반논문[19941001] Activation and tyrosine phosphorylation of 44KDa mitrogen activated protein kianse(MAPK) induced by
• 일반논문[19940729] Phosphorylation and activation of mitogen-activated protein kinase by kainic acid induced seizure in
• 일반논문[19930228] 소뇌 GUANINE Aminohydrolase의 정제
• 저서/역서[20060820] 레닌저 생화학 제 4판
• 저서/역서[20050201] 리핀코트의 그림으로 보는 생화학
• 저서/역서[19990225] 현대인의 건강
• 학술발표[20170622] Dual inhibition of EGFR and MET induces synthetic lethality in triple negative breast cancer cells through downregulation of ribosomal protein S6
• 학술발표[20130409] Inhibition of checkpoint kinase 2 enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine
• 학술발표[20121011] The antitumor effect(s) by BML-275, AMPK inhibitor in pancreatic adenocarcinoma cells
• 학술발표[20121011] Inhibition of checkpoint kinase 2(CHK2) significantly enhances sensitivity of pancreatic adenocarcinoma cells to gemcitabine
• 학술발표[20121011] Aldhyde dehydrogenase1A1 (ADDH1A1) confers intrinsic and acquired gemcitabine resistance to pancreatic adenocarcinoma cells
• 학술발표[20120601] Targeting IKK-2 to enhance anti-tumor effect of gemcitabine in pancreatic cancer cell model
• 학술발표[20120531] Synergistic effect exhibited by combinational treatment of Gemcitabine and checkpoint kinase inhibitors
• 학술발표[20120531] TGFBR1 inhibitor sensitizes drug resistant pancreatic cells to gemcitabine
• 학술발표[20111014] Anti apoptotic role of ODF2 variant, cenexin1
• 학술발표[20100519] CCDC110 Protein is frequenctly overexpressed in uterine cerical cancer
• 학술발표[20100518] Direct inhibition of cdks can induce heterochromatin formation associated with cyclin A suppression in WI 38 HDF cells but cannot in cancer cells
• 학술발표[20080509] Direct inhibition of cdks by BMI-1026 treatment can induce SAHF formation by activation of Erk1/2 and SAHF
• 학술발표[20080508] Production and characterization analysis of newly established KM-HN-1 (MGC33607) monoclonal antibodies
• 학술발표[20061026] BMI-1026 Treatment Can indice Premature Senescence Like change in HDF Cell line
• 학술발표[20060525] KM-HN1 a new cancer/testis antigen is centrosome localizing protein and disruption of in induces retarded cell growth and cell death
• 학술발표[20051026] MGC33607 is centrosomal locaizing protein and knock-down by RNAi induces some mitotic defect
• 학술발표[20040604] A novel Cdk Inhibitor, BMI-1026, Inhibits Cell Cycle Progression and Induces Apoptosis In Human U2-OS cells
• 학술발표[19980501] Characterization of alteration of alteration of G1 cell cycle regulators in cell lines over-expressi
• 학술발표[19970424] Molecular screening and analysis of recombinationt ligand proteins associating with unique-sh3 domain of c-YES
• 학술발표[19961101] Electroconvulsive shock induced acitvation of transcription factor CREB in rat brain
• 학술발표[19961025] Molecular cloning and sequencing of guanine aminohydrolase cDNA
• 학술발표[19951025] Induction of c-fos and TIS8, and Phosphorylation of CREB and MAPK by Electroconvulsive Shock in Developing rat Brain
• 학술발표[19951021] Induction of IEGs by electroconvulsive in developing rat brain
• 학술발표[19950615] 다클론항체를 이용한 흰쥐 뇌 guanine aminohydrolase c-DNA의 클로닝
• 학술발표[19950321] The increase of p185 in a stomach cancer cell line by the protein synthsis
• 학술발표[19940325] Genomic sequences in a stomach and a colon cancer DNA which hybridized to c-erbB2 cDNA

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