단국대학교

• 학과소개
• 교수소개
• 교과과정

교수소개

대학원 박사과정중 세포내 에너지와 활성산소를 생산하는 미토콘드리아의 전자전달계 효소인 시토크롬 씨 옥시다제의 활성을 조절하는 기작을 연구하였습니다. 그후 연구원과정동안 암과 뇌질환등 인간의 여러질병들과 미토콘드리아 기능이상의 상관관계에 대해서 연구했습니다. 또한 시토크롬 씨 옥시다제의 폐조직특이적 동위효소의 기능을 유전자형질변형 생쥐연구를 통해서 밝혀내었습니다. 그리고 뇌졸증과 심장마비후 야기되는 세포파괴를 막을수 있는 원적외선 치료를 연구하여 미국 특허를 출원했습니다. 현재 여러 질병에서 보여지는 미토콘드리아의 기능장애 기작을, 특히 세포신호체계의 역할에 대해서 연구하고 있습니다.

교육철학

고등교육의 목표는 생명의 존엄성을 인지하고, 사명감과 책임감을 가지며, 전문적인 지식과 기술을 습득하고, 논리적 분석과 객관성을 바탕으로 창의적으로 문제를 해결하수 있는 능력을 갖춘 인재를 양성하는 것이라고 생각합니다. 단국 대학교의 ‘세계로 도약하는 민족사학’이라는 교육비전 하에 학생들이 현대사회의 치열한 경쟁 속에서도 더불어 협동하며, 지역사회 그리고 더 나아가 세계, 인류사회의 발전에 공헌할 수 있는 인재로 커 나가도록 교육자로서 돕는 것이 교육 철학이자 목표입니다.

학력

• [1996] 학사 숙명여자대학교 / 물리·화학·생물학과군
• [1998] 석사 숙명여자대학교 / 물리·화학·생물학과군
• [2001] 박사 Philipps - Univ. Marburg / 화학과 생화학전공

주요연구분야

Cell signaling pathways targeting mitochondria
Cellular respiration in cancers & neurodegenerative diseases
Signal transduction targeting mitochondria in human diseases
Tissue specific isozymes

컨설팅 가능 분야

Enzyme biochemistry
Mitochondrial bioenergetiecs
Signal transduction

연구업적

• 일반논문[20230713] Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle
• 일반논문[20230501] Non-invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near-infrared light into the human brain through soft skin-conforming silicone waveguides
• 일반논문[20221001] Sometimes less is more: inhibitory infrared light during early reperfusion calms hyperactive mitochondria and suppresses reperfusion injury
• 일반논문[20210801] Mitochondrial respiration is controlled by Allostery, Subunit Composition and Phosphorylation Sites of Cytochrome c Oxidase: A trailblazer's tale - Bernhard Kadenbach
• 일반논문[20210601] Regulation of Cytochrome c Oxidase by Natural Compounds Resveratrol, (-)-Epicatechin, and Betaine
• 일반논문[20210401] Lysine 53 Acetylation of Cytochrome c in Prostate Cancer: Warburg Metabolism and Evasion of Apoptosis
• 일반논문[20210101] Rutin inhibits DRP1-mediated mitochondrial fission and prevents ethanol-induced hepatotoxicity in HepG2 cells and zebrafish
• 일반논문[20201101] Cytochrome c oxidase-modulatory near-infrared light penetration into the human brain: Implications for the noninvasive treatment of ischemia/reperfusion injury
• 일반논문[20200801] Brain-Specific Serine-47 Modification of CytochromecRegulates CytochromecOxidase Activity Attenuating ROS Production and Cell Death: Implications for Ischemia/Reperfusion Injury and Akt Signaling
• 일반논문[20200401] Non-invasive treatment with near-infrared light: A novel mechanisms-based strategy that evokes sustained reduction in brain injury after stroke
• 일반논문[20200401] Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis
• 일반논문[20191201] Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity
• 일반논문[20191101] Regulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation
• 일반논문[20190201] Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis
• 일반논문[20181212] Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue
• 일반논문[20180501] AEROBIC EXERCISE PRECONCEPTION AND DURING PREGNANCY ENHANCES OXIDATIVE CAPACITY IN THE HINDLIMB MUSCLES OF MICE OFFSPRING
• 일반논문[20180401] Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury (vol 8, 2018)
• 일반논문[20180201] Mitochondrial Structure, Function, and Dynamics: The Common Thread across Organs, Disease, and Aging
• 일반논문[20170801] HPV-associated differential regulation of tumor metabolism in oropharyngeal head and neck cancer
• 일반논문[20170501] Tissue-and Condition-Specific Isoforms of Mammalian Cytochrome c Oxidase Subunits: From Function to Human Disease
• 일반논문[20170101] Phosphorylation of Cytochrome c Threonine 28 Regulates Electron Transport Chain Activity in Kidney IMPLICATIONS FOR AMP KINASE
• 일반논문[20160901] ATP5B regulates mitochondrial fission and fusion in mammalian cells
• 일반논문[20160801] COX7AR is a stress inducible mitochondrial COX subunit that promotes breast cancer malignancy
• 일반논문[20160101] (-)- EPICATECHIN ATTENUATES DEGRADATION OF MOUSE OXIDATIVE MUSCLE FOLLOWING HINDLIMB SUSPENSION
• 일반논문[20150901] Inhibition of N-Methyl-d-aspartate-induced Retinal Neuronal Death by Polyarginine Peptides Is Linked to the Attenuation of Stress-induced Hyperpolarization of the Inner Mitochondrial Membrane Potential.
• 일반논문[20150801] Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines
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• 일반논문[20150301] (-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice
• 일반논문[20150101] Betaine is a positive regulator of mitochondrial respiration.
• 일반논문[20150101] MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism
• 일반논문[20141101] Hypoxic stress induces, but cannot sustain trophoblast stem cell differentiation to labyrinthine placenta due to mitochondrial insufficiency
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• 일반논문[20140430] Regulation of cytochrome c in respiration, apoptosis, neurodegeneration and cancer: the good, the bad and the ugly
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• 일반논문[20140301] Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats
• 일반논문[20140207] Deletion of the Cardiolipin-specific Phospholipase Cld1 Rescues Growth and Life Span Defects in the Tafazzin Mutant IMPLICATIONS FOR BARTH SYNDROME
• 일반논문[20140206] Epicatechin Stimulates Mitochondrial Activity and Selectively Sensitizes Cancer Cells to Radiation
• 일반논문[20131101] Cytochrome c Is Tyrosine 97 Phosphorylated by Neuroprotective Insulin Treatment
• 일반논문[20130601] (-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity
• 일반논문[20130301] Similar skeletal muscle angiogenic and mitochondrial signalling following 8 weeks of endurance exercise in mice: discontinuous versus continuous training
• 일반논문[20121001] Deletion of heart-type cytochrome c oxidase subunit 7a1 impairs skeletal muscle angiogenesis and oxidative phosphorylation
• 일반논문[20120901] Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology
• 일반논문[20120501] Phosphorylation of mammalian cytochrome c and cytochrome c oxidase in the regulation of cell destiny: Respiration, apoptosis, and human disease
• 일반논문[20120401] Regulation of mitochondrial respiration and apoptosis through cell signaling: Cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation
• 일반논문[20120401] (-)-Epicatechin maintains endurance training adaptation in mice after 14 days of detraining
• 일반논문[20120401] Multiple phosphorylations of cytochrome c oxidase and their functions
• 일반논문[20120301] TLR4-Mediated AKT Activation Is MyD88/TRIF Dependent and Critical for Induction of Oxidative Phosphorylation and Mitochondrial Transcription Factor A in Murine Macrophages
• 일반논문[20120301] Mice deleted for heart-type cytochrome c oxidase subunit 7a1 develop dilated cardiomyopathy
• 일반논문[20120301] TXNIP Links Innate Host Defense Mechanisms to Oxidative Stress and Inflammation in Retinal Muller Glia under Chronic Hyperglycemia: Implications for Diabetic Retinopathy
• 일반논문[20110501] The multiple functions of cytochrome c and their regulation in life and death decisions of the mammalian cell: From respiration to apoptosis
• 일반논문[20100801] Phosphomimetic Substitution of Cytochrome c Tyrosine 48 Decreases Respiration and Binding to Cardiolipin and Abolishes Ability to Trigger Downstream Caspase Activation
• 일반논문[20100701] Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function
• 일반논문[20100601] Theophylline treatment improves mitochondrial function after upper cervical spinal cord hemisection
• 일반논문[20100201] A suggested role for mitochondria in Noonan syndrome
• 일반논문[20091201] Epidermal Growth Factor Receptor Translocation to the Mitochondria REGULATION AND EFFECT
• 일반논문[20090901] Mitochondrial Dysfunction in a Neural Cell Model of Spinal Muscular Atrophy
• 일반논문[20090801] Different proteolipid protein mutants exhibit unique metabolic defects
• 일반논문[20090301] ISOLATION OF REGULATORY-COMPETENT, PHOSPHORYLATED CYTOCHROME C OXIDASE
• 일반논문[20081001] Regulation of oxidative phosphorylation, the mitochondrial membrane potential, and their role in human disease
• 일반논문[20080701] Tumor necrosis factor alpha inhibits oxidative phosphorylation through tyrosine phosphorylation at subunit I of cytochrome c oxidase
• 학술발표[20130617] Phosphorylation of Bovine kidney cytochrome c
• 학술발표[20130617] (-)-Epicatechin improves mitochondrial function through activation of cytochrome c oxidase
• 학술발표[20130514] The role of cytochrome c oxidase subunit 4 isoform 2 in lung physiology
• 학술발표[20130506] Do mitochondria cause essential hypertension? Increased renal proximal tubule bioenergetic activity prior to the onset of sustained hypertension in spontaneously hypertensive rats
• 학술발표[20130506] CHCHD2, a new regulator of mitochondrial metabolism

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